Article
Gut cryptopatches: direct evidence of extrathymic anatomical sites for intestinal T lymphopoiesis.
Immunity - 1 Nov 2000
Suzuki K, Oida T, Hamada H, Hitotsumatsu O, Watanabe M, Hibi T, Yamamoto H, Kubota E, Kaminogawa S, Ishikawa H
Abstract excerpt
Athymic cytokine receptor gamma chain mutant mice that lack the thymus, Peyer's patches, cryptopatches (CP), and intestinal T cells were reconstituted with wild-type bone marrow cells. Bone marrow-derived TCR(-) intraepithelial lymphocytes (IEL) first appeared within villous epithelia of small intestine overlying the regenerated CP, and these TCR(-) IEL subsequently emerged throughout the epithelia. Thereafter,...
Topics
- Animals
- Cell Differentiation
- Cell Lineage
- Immunity, Mucosal
- Intestines
- Mice
- Mice, Nude
- Mutation
- T-Lymphocytes