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Article

Characterization of spontaneous and induced mutations in SV40-transformed normal and ataxia telangiectasia cell lines.

Somatic cell and molecular genetics - 1 Nov 1994

Röscheisen C, Haupter S, Zechner U, Speit G

Abstract excerpt

Spontaneous and induced mutations at the HPRT locus were analyzed in one normal (MRC5CV1) and one ataxia telangiectasia (AT5BIVA) SV40-transformed cell line derived from male donors. Multiplex PCR and Southern analyses revealed a high frequency of spontaneous deletion mutations that may be a cons...

Topics

Ataxia Telangiectasia
Base Sequence
Bleomycin
Blotting, Southern
Cell Line
Cell Transformation, Viral
Doxorubicin
Humans
Hypoxanthine Phosphoribosyltransferase
In Situ Hybridization
Male
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

Mutagens

Mutation

Polymerase Chain Reaction

Sequence Deletion

Source

Identifiers

PMID: 7534443
DOI: 10.1007/BF02255840

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7534443-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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