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Article

Characterization of spontaneous and induced mutations in SV40-transformed normal and ataxia telangiectasia cell lines.

Somatic cell and molecular genetics - 1 Nov 1994

Röscheisen C, Haupter S, Zechner U, Speit G

Abstract excerpt

Spontaneous and induced mutations at the HPRT locus were analyzed in one normal (MRC5CV1) and one ataxia telangiectasia (AT5BIVA) SV40-transformed cell line derived from male donors. Multiplex PCR and Southern analyses revealed a high frequency of spontaneous deletion mutations that may be a consequence of the SV40 transformation. Four mutagens (ethyl methanesulfonate, bromodeoxyuridine, bleomycin, adriamycin),...

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PMID: 7534443
DOI: 10.1007/BF02255840

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BLM

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