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Spectrum of in vivo hprt mutations in T lymphocytes from atomic bomb survivors. I. Sequence alterations in cDNA.

Carcinogenesis - 1 Mar 1995

Shimahara H, Kato T, Hirai Y, Akiyama M

Abstract excerpt

Recently, we found an elevated frequency of 6-thioguanine-resistant (TGr) mutations at the hyoxanthine-guanine phosphoribosyltransferase (hprt) gene in T cells of peripheral blood from atomic bomb survivors and a slight, but significant, positive correlation between the frequency of mutation and radiation dose. Southern blot analysis of DNA from TGr mutant T cells of atomic bomb survivors, however, failed to show...

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PMID: 7697817
DOI: 10.1093/carcin/16.3.583

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Spectrum of in vivo hprt mutations in T lymphocytes from atomic bomb survivors. I. Sequence alterations in cDNA.PMID 7697817Read ↗

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