Article
Spectrum of in vivo hprt mutations in T lymphocytes from atomic bomb survivors. I. Sequence alterations in cDNA.
Carcinogenesis - 1 Mar 1995
Shimahara H, Kato T, Hirai Y, Akiyama M
Abstract excerpt
Recently, we found an elevated frequency of 6-thioguanine-resistant (TGr) mutations at the hyoxanthine-guanine phosphoribosyltransferase (hprt) gene in T cells of peripheral blood from atomic bomb survivors and a slight, but significant, positive correlation between the frequency of mutation and radiation dose. Southern blot analysis of DNA from TGr mutant T cells of atomic bomb survivors, however, failed to show...
Topics
- Adult
- Aged
- Base Sequence
- DNA Mutational Analysis
- DNA Primers
- DNA, Complementary
- Exons
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Male
- Middle Aged
- Molecular Sequence Data