Mutation spectrum in gamma-irradiated shuttle vector replicated in ataxia-telangiectasia lymphoblasts.

Article

Mutation spectrum in gamma-irradiated shuttle vector replicated in ataxia-telangiectasia lymphoblasts.

Radiation research - 1 Jun 1992

Sikpi M O, Freedman M L, Dry S M, Lurie A G

Abstract excerpt

Cells from ataxia-telangiectasia (AT) patients are hypersensitive to the lethal effects of ionizing radiation. To assess radiation mutagenesis in these cells, the SV40-based shuttle vector, pZ189, was used to analyze gamma-ray-induced mutations following the plasmid's replication in AT lymphoblas...

Topics

Ataxia Telangiectasia
Base Sequence
Chromosome Deletion
DNA Replication
Genetic Vectors
Humans
In Vitro Techniques
Lymphocytes
Molecular Sequence Data
Mutation

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