Article
A Saccharomyces cerevisiae mutant defines a new locus essential for resistance to the antitumour drug bleomycin.
Canadian journal of microbiology - 1 Aug 1996
Ramotar D, Masson J Y
Abstract excerpt
The antitumor drug bleomycin can produce a variety of lesions in the cellular DNA by a free radical dependent mechanism. To understand how these DNA lesions are repaired, bleomycin-hypersensitive mutants were isolated from the yeast Saccharomyces cerevisiae. We report here the analysis of one mut...
Topics
- Antibiotics, Antineoplastic
- Bleomycin
- Crosses, Genetic
- DNA Repair
- DNA-Binding Proteins
- Drug Resistance, Microbial
- Fungal Proteins
- Genetic Complementation Test
- Ligases
- Microbial Sensitivity Tests
- Mutation
- Phenotype
- Rad52 DNA Repair and Recombination Protein
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Translocation, Genetic
- Ubiquitin-Conjugating Enzymes