Article
Inactivation of RAD52 aggravates RAD54 defects in mice but not in Schizosaccharomyces pombe.
DNA repair - 28 Sept 2005
de Vries Femke A T, Zonneveld José B M, van Duijn-Goedhart Annemarie, Roodbergen Marianne, Boei Jan, van Buul Paul P W, Essers Jeroen, van Steeg Harry, van Zeeland Albert A, van Benthem Jan, Pastink Albert
Abstract excerpt
RAD52 and RAD54 genes from Saccharomyces cerevisiae are required for double-strand break repair through homologous recombination and show epistatic interactions i.e., single and double mutant strains are equally sensitive to DNA damaging agents. In here we combined mutations in RAD52 and RAD54 homologs in Schizosaccharomyces pombe and mice. The analysis of mutant strains in S. pombe demonstrated nearly identical...
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