Article
A role for histone H2B during repair of UV-induced DNA damage in Saccharomyces cerevisiae.
Genetics - 1 Apr 2002
Martini Emmanuelle M D, Keeney Scott, Osley Mary Ann
Abstract excerpt
To investigate the role of the nucleosome during repair of DNA damage in yeast, we screened for histone H2B mutants that were sensitive to UV irradiation. We have isolated a new mutant, htb1-3, that shows preferential sensitivity to UV-C. There is no detectable difference in bulk chromatin structure or in the number of UV-induced cis-syn cyclobutane pyrimidine dimers (CPD) between HTB1 and htb1-3 strains. These...
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