Article
DNA repair in radiation sensitive mutants of mammalian cells: possible involvement of DNA topoisomerases.
International journal of radiation biology - 1 Oct 1990
Hickson I D, Davies S L, Davies S M, Robson C N
Abstract excerpt
Mutants are invaluable in the study of DNA repair processes. The past 10 years have seen a rapid proliferation of papers describing the isolation of mammalian cell mutants exhibiting DNA repair abnormalities. A variety of DNA-damaging agents, including radiation, alkylating agents and bleomycin, have been used to select mutants. This mini-review will concentrate on radiation (particularly ionizing...
Topics
- Animals
- Cricetinae
- DNA Repair
- DNA Topoisomerases, Type I
- DNA Topoisomerases, Type II
- Enzyme Inhibitors
- Humans
- In Vitro Techniques
- Mice
- Mutation
- Radiation Tolerance