Article
The HMG-domain protein Ixr1 blocks excision repair of cisplatin-DNA adducts in yeast.
Mutation research - 2 Jan 1996
McA'Nulty M M, Lippard S J
Abstract excerpt
Ixr1 is a yeast HMG-domain protein which binds the major DNA adducts of the antitumor drug cisplatin. Previous work demonstrated that Saccharomyces cerevisiae cells lacking the IXR1 gene were two-fold less sensitive to cisplatin treatment than wild-type cells, and the present investigation reveal...
Topics
- Antineoplastic Agents
- Cell Cycle
- Cell Cycle Proteins
- Cisplatin
- DNA Adducts
- DNA Repair
- DNA Repair Enzymes
- DNA, Fungal
- DNA-Binding Proteins
- Drug Resistance, Microbial
- Endodeoxyribonucleases
- Endonucleases
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal
- High Mobility Group Proteins
- Ligases
- Mutagens