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Article

The HMG-domain protein Ixr1 blocks excision repair of cisplatin-DNA adducts in yeast.

Mutation research - 2 Jan 1996

McA'Nulty M M, Lippard S J

Abstract excerpt

Ixr1 is a yeast HMG-domain protein which binds the major DNA adducts of the antitumor drug cisplatin. Previous work demonstrated that Saccharomyces cerevisiae cells lacking the IXR1 gene were two-fold less sensitive to cisplatin treatment than wild-type cells, and the present investigation reveals a six-fold difference in yeast having a different background. The possibility that the lower cytotoxicity of...

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Source

Identifiers

PMID: 8538651
DOI: 10.1016/0921-8777(95)00037-2

Genes

RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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