Oncogenic activation of v-kit involves deletion of a putative tyrosine-substrate interaction site.

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Article

Oncogenic activation of v-kit involves deletion of a putative tyrosine-substrate interaction site.

Oncogene - 19 Jan 1995

Herbst R, Munemitsu S, Ullrich A

Abstract excerpt

The transforming gene of the Hardy-Zuckerman-4 strain of feline sarcoma virus, v-kit, arose by transduction of the cellular c-kit gene, which encodes the receptor tyrosine kinase (RTK) p145c-kit. To gain insight into the molecular basis of the v-kit transforming potential, we characterized the feline c-kit by cDNA cloning. Comparison of the feline v-kit and c-kit sequences revealed, in addition to deletions of...

Topics

3T3 Cells
Amino Acid Sequence
Animals
Base Sequence
Cats
Cell Transformation, Viral
Cloning, Molecular
Genes, Viral
Mice
Molecular Sequence Data
Mutagenesis
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphatidylinositol 3-Kinases

Phosphorylation

Phosphotransferases (Alcohol Group Acceptor)

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-kit

Receptor Protein-Tyrosine Kinases

Source

Open in PubMed

Identifiers

PMID: 7530827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7530827-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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