Article
Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1.
Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 1996
Piao X, Paulson R, van der Geer P, Pawson T, Bernstein A
Abstract excerpt
Activating mutations in the Kit receptor tyrosine kinase have been identified in both rodent and human mast cell leukemia. One activating Kit mutation substitutes a valine for aspartic acid at codon 816 (D816V) and is frequently observed in human mastocytosis. Mutation at the equivalent position...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- Humans
- Intracellular Signaling Peptides and Proteins
- Mast Cells
- Mice
- Molecular Sequence Data
- Mutation
- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatases