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Article

The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.

Molecular cell - 8 Jan 2015

Reshetnyak Andrey V, Opatowsky Yarden, Boggon Titus J, Folta-Stogniew Ewa, Tome Francisco, Lax Irit, Schlessinger Joseph

Abstract excerpt

The receptor tyrosine kinase KIT plays an important role in development of germ cells, hematopoietic cells, and interstitial pacemaker cells. Oncogenic KIT mutations play an important "driver" role in gastrointestinal stromal tumors, acute myeloid leukemias, and melanoma, among other cancers. Here we describe the crystal structure of a recurring somatic oncogenic mutation located in the C-terminal Ig-like domain...

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Source

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Identifiers

PMID: 25544564
DOI: 10.1016/j.molcel.2014.11.021
PMCID: PMC4764128

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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