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Article

A change in structural integrity of c-Kit mutant D816V causes constitutive signaling.

Mutation research - 1 Mar 2018

Raghav Pawan Kumar, Singh Ajay Kumar, Gangenahalli Gurudutta

Abstract excerpt

Several signaling pathways, ligands, and genes that regulate proliferative and self-renewal properties of the Hematopoietic Stem Cells (HSCs) have been studied meticulously. One of the signaling pathways that play a crucial role in the process of hematopoiesis is the Stem Cell Factor (SCF) mediated c-Kit pathway. The c-Kit is a Receptor Tyrosine Kinase (RTK), which is expressed in the cells including HSCs. It...

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PMID: 29482074
DOI: 10.1016/j.mrfmmm.2018.02.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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