Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptor.

doi:10.1038/sj.onc.1201994

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptor.

Oncogene - 13 Aug 1998

Santoro M M, Penengo L, Minetto M, Orecchia S, Cilli M, Gaudino G

Abstract excerpt

Ron (the receptor for Macrophage Stimulating Protein) has never been implicated before in human malignancies or in cell transformation. In this report we show that Ron can acquire oncogenic potential by means of two amino acid substitutions-D1232V and M1254T-affecting highly conserved residues in...

Topics

3T3 Cells
Animals
COS Cells
Calcium-Calmodulin-Dependent Protein Kinases
Cell Transformation, Neoplastic
Drosophila Proteins
HeLa Cells
Humans
JNK Mitogen-Activated Protein Kinases
Lung Neoplasms
Mice
Mice, Nude
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinases
Neoplasm Metastasis
Oncogenes
Phenotype
Phosphorylation

Source

Open in PubMed

Identifiers

PMID: 9715276
DOI: 10.1038/sj.onc.1201994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9715276-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics