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Article

Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptor.

Oncogene - 13 Aug 1998

Santoro M M, Penengo L, Minetto M, Orecchia S, Cilli M, Gaudino G

Abstract excerpt

Ron (the receptor for Macrophage Stimulating Protein) has never been implicated before in human malignancies or in cell transformation. In this report we show that Ron can acquire oncogenic potential by means of two amino acid substitutions-D1232V and M1254T-affecting highly conserved residues in the tyrosine kinase domain. The same mutations in Kit and Ret have been found associated with two human malignancies,...

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PMID: 9715276
DOI: 10.1038/sj.onc.1201994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptor.PMID 9715276Read ↗

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