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Article

The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction.

The Journal of biological chemistry - 24 Apr 2009

Sun Jianmin, Pedersen Malin, Rönnstrand Lars

Abstract excerpt

The receptor tyrosine kinase c-Kit plays a critical role in hematopoiesis, and gain-of-function mutations of the receptor are frequently seen in several malignancies, including acute myeloid leukemia, gastrointestinal stromal tumors, and testicular carcinoma. The most common mutation of c-Kit in these disorders is a substitution of the aspartic acid residue in position 816 to a valine (D816V), leading to...

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Identifiers

PMID: 19265199
DOI: 10.1074/jbc.M808058200
PMCID: PMC2670109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction.PMID 19265199Read ↗

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