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Article

The c-Kit/D816V mutation eliminates the differences in signal transduction and biological responses between two isoforms of c-Kit.

Cellular signalling - 1 Mar 2009

Pedersen M, Rönnstrand L, Sun J

Abstract excerpt

Activating mutations of codon 816 of the Kit gene have been implicated in malignant cell growth of acute myeloid leukemia (AML), systemic mastocytosis and germ cell tumors. Substitution of aspartic acid with valine (D816V) renders the receptor independent of ligand for activation and signaling. Wild-type c-Kit is a tyrosine kinase receptor that requires its ligand, stem cell factor (SCF), for activation. Several...

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Source

Identifiers

PMID: 19049823
DOI: 10.1016/j.cellsig.2008.11.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The c-Kit/D816V mutation eliminates the differences in signal transduction and biological responses between two isoforms of c-Kit.PMID 19049823Read ↗

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