A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors.

doi:10.1016/s0016-5085(98)70079-4

Article

A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors.

Gastroenterology - 1 Nov 1998

Nakahara M, Isozaki K, Hirota S, Miyagawa J, Hase-Sawada N, Taniguchi M, Nishida T, Kanayama S, Kitamura Y, Shinomura Y, Matsuzawa Y

Abstract excerpt

BACKGROUND & AIMS: The c-kit gene encodes a receptor tyrosine kinase (KIT). Recently, we found gain-of-function mutations of the c-kit gene in gastrointestinal stromal tumors (GISTs). All mutations were confined within the 11 amino acids (Lys-550 to Val-560) in the juxtamembrane domain, but one G...

Topics

Amino Acid Sequence
Animals
Base Sequence
DNA, Complementary
Gastrointestinal Neoplasms
Humans
Mesenchymoma
Mice
Mice, Nude
Mutation
Proto-Oncogene Proteins c-kit
Transfection

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