Article
The tyrosine kinase FES is an essential effector of KITD816V proliferation signal.
Blood - 1 Oct 2007
Voisset Edwige, Lopez Sophie, Dubreuil Patrice, De Sepulveda Paulo
Abstract excerpt
KIT is a tyrosine kinase receptor that is aberrantly activated in several neoplasms. In human pathologies, the most frequent mutation of KIT occurs at codon 816. The resulting KIT mutant protein is activated in the absence of ligand and is resistant to the clinically available inhibitors of KIT. In this report, we provide evidence for an essential function of the cytoplasmic tyrosine kinase FES downstream of...
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