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Article

TGF-beta-induced apoptosis in human thyrocytes is mediated by p27kip1 reduction and is overridden in neoplastic thyrocytes by NF-kappaB activation.

Oncogene - 30 Oct 2003

Bravo Susana B, Pampín Sandra, Cameselle-Teijeiro José, Carneiro Carmen, Domínguez Fernando, Barreiro Francisco, Alvarez Clara V

Abstract excerpt

Millions of people worldwide suffer goiter, a proliferative disease of the follicular cells of the thyroid that may become neoplastic. Thyroid neoplasms have low proliferative index, low apoptotic index and a high incidence of metastasis. TGF-beta is overexpressed in thyroid follicular tumor cells. To investigate the role of TGF-beta in thyroid tumor progression, we established cultures of human thyrocytes from...

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Identifiers

PMID: 14586408
DOI: 10.1038/sj.onc.1207029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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