Article
Stepwise participation of p53 gene mutation during dedifferentiation of human thyroid carcinomas.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Mar 1994
Dobashi Y, Sugimura H, Sakamoto A, Mernyei M, Mori M, Oyama T, Machinami R
Abstract excerpt
The spectrum of p53 gene mutations was investigated in thyroid carcinomas with respect to histopathological classification. In all histological subtypes of thyroid carcinoma that had previously revealed positivity in immunohistochemical staining for p53 protein, single-stranded conformation polymorphism analysis and direct sequencing were performed to detect point mutations between exons 5 and 8. In well...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Differentiation
- DNA, Neoplasm
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Polymerase Chain Reaction