Article
Tissue-specific mutant frequencies and mutational spectra in cyclophosphamide-treated lacI transgenic mice.
Environmental and molecular mutagenesis - 1 Jan 1999
Gorelick N J, Andrews J L, deBoer J G, Young R, Gibson D P, Walker V E
Abstract excerpt
The induction and nature of mutations in the lacI transgene were evaluated in multiple tissues after exposure of adult male B6C3F1 lacI transgenic mice to cyclophosphamide (CP). Mice were given a single i.p. injection of 25 mg CP/kg, 100 mg CP/kg, or vehicle (PBS) and then necropsied 6 weeks after treatment to allow DNA extraction and lacI mutant recovery. Tissues evaluated included target tissues for...
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