Article
Deregulated c-myc expression is insufficient for emergence of the tumorigenic phenotype in malignancy-suppressed intratypic T-cell lymphoma hybrids: an in vitro model for multistep lymphomagenesis.
Cancer letters - 29 Mar 1996
Kubota K, Tamauchi H, Nakazato K
Abstract excerpt
The T-cell lymphoma cell line YACUT was fused with the Mls-1a antigen-responsive non-tumorigenic T-cell line G4 to construct growth-arrested hybrids which could be induced to proliferate in the presence of Mls-1a antigen. Prolonged growth of the hybrids by repeated antigenic stimulation resulted...
Topics
- Animals
- Carcinogenicity Tests
- Cell Transformation, Neoplastic
- Chromosomes, Human, Pair 15
- Gene Rearrangement
- Humans
- Hybrid Cells
- Lymphoma, T-Cell
- Mice
- Mice, Inbred A
- Mice, Inbred C3H
- Neoplasm Transplantation
- Phenotype
- Proto-Oncogene Proteins c-myc
- RNA, Messenger
- Tumor Cells, Cultured