Article
Targets of extinction: identification of genes whose expression is repressed as a consequence of somatic fusion between cells representing basal and luminal mammary epithelial phenotypes.
Journal of cell science - 1 Feb 2000
MacDougall J R, Matrisian L M
Abstract excerpt
The use of somatic cell hybrids has led to an increased understanding of the 'negative' regulation of cellular phenotype. Using somatic cell hybrids constructed between human breast cells that represent differing stages of malignancy but also display differing phenotypes from the same tissue, we present experimental results suggesting that luminal epithelial characteristics are controlled by repressive...
Topics
- Adenocarcinoma
- Antigens, Neoplasm
- Biological Factors
- Biomarkers
- Breast
- Breast Neoplasms
- Cadherins
- Cell Adhesion Molecules
- Cell Differentiation
- Cell Fusion
- Cell Lineage
- Cell Nucleus
- Cytoplasm
- Epistasis, Genetic