Article
Reversion and cell hybridization of a dedifferentiated rat hepatoma cell: dissociation of mechanisms establishing the hepatic traits.
Experimental cell research - 1 Jul 1993
Ng K H, Maigné J, Fougère-Deschatrette C, Poupon M F, Deschatrette J
Abstract excerpt
The expression of a mouse serum albumin (MSA) gene introduced into differentiated and dedifferentiated variant cells of a rat hepatoma line depends on the overall differentiated state of the recipient cell. Thus, the transcription rate of this mouse gene is very high in differentiated cells compa...
Topics
- Animals
- Cell Differentiation
- Clone Cells
- Gene Expression Regulation, Neoplastic
- Hybrid Cells
- Liver Neoplasms, Experimental
- Mice
- Phenotype
- RNA, Messenger
- Rats
- Serum Albumin
- Transcription, Genetic
- Transfection
- Tumor Cells, Cultured