Article
Reversion and cell hybridization of a dedifferentiated rat hepatoma cell: dissociation of mechanisms establishing the hepatic traits.
Experimental cell research - 1 Jul 1993
Ng K H, Maigné J, Fougère-Deschatrette C, Poupon M F, Deschatrette J
Abstract excerpt
The expression of a mouse serum albumin (MSA) gene introduced into differentiated and dedifferentiated variant cells of a rat hepatoma line depends on the overall differentiated state of the recipient cell. Thus, the transcription rate of this mouse gene is very high in differentiated cells compared to that in the variant. Furthermore, the activation of its expression is observed during the course of reversion of...
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