Heterologous protein expression by transimmortalized differentiated liver cell lines derived from transgenic mice (hepatomas/alpha 1 antitrypsin/ONC mouse).

doi:10.1016/1045-1056(90)90006-l

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Article

Heterologous protein expression by transimmortalized differentiated liver cell lines derived from transgenic mice (hepatomas/alpha 1 antitrypsin/ONC mouse).

Biologicals : journal of the International Association of Biological Standardization - 1 Jul 1990

Dalemans W, Perraud F, Le Meur M, Gerlinger P, Courtney M, Pavirani A

Abstract excerpt

A number of therapeutic plasma proteins are synthesized by human hepatocytes. Since many of these proteins undergo liver-specific post-translational modifications which are required for full biological activity, it may therefore be necessary to develop hepatocyte-based expression systems for thei...

Topics

Animals
Base Sequence
Cell Transformation, Neoplastic
Culture Media
Genes, myc
Liver
Liver Neoplasms, Experimental
Mice
Mice, Transgenic
Molecular Sequence Data
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Protein Processing, Post-Translational

Proto-Oncogene Mas

Recombinant Proteins

Tumor Cells, Cultured

alpha 1-Antitrypsin

Source

Open in PubMed

Identifiers

PMID: 2257132
DOI: 10.1016/1045-1056(90)90006-l

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2257132-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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