Article
Heterologous protein expression by transimmortalized differentiated liver cell lines derived from transgenic mice (hepatomas/alpha 1 antitrypsin/ONC mouse).
Biologicals : journal of the International Association of Biological Standardization - 1 Jul 1990
Dalemans W, Perraud F, Le Meur M, Gerlinger P, Courtney M, Pavirani A
Abstract excerpt
A number of therapeutic plasma proteins are synthesized by human hepatocytes. Since many of these proteins undergo liver-specific post-translational modifications which are required for full biological activity, it may therefore be necessary to develop hepatocyte-based expression systems for their production. Using transgenic mice we have developed a transimmortalisation technique for the isolation of...
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