Article
Molecular analysis of the TP53 gene in Barrett's adenocarcinoma.
Human mutation - 1 Jan 1996
Audrézet M P, Robaszkiewicz M, Mercier B, Nousbaum J B, Hardy E, Bail J P, Volant A, Lozac'h P, Gouérou H, Férec C
Abstract excerpt
The TP53 gene is the most frequently mutated gene in human cancers. Barrett's esophagus provides an excellent model by which to understand the genetic events that lead from dysplasia to cancer. We screened for mutations in the TP53 gene by a combination of denaturing gradient gel electrophoresis and DNA sequencing in ten cases of adenocarcinoma arising in Barrett's mucosa. We have identified missense mutations in...
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