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Article

Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21.

American journal of human genetics - 1 Apr 1993

Smith S A, Easton D F, Ford D, Peto J, Anderson K, Averill D, Stratton M, Ponder M, Pye C, Ponder B A

Abstract excerpt

In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at theta = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250.

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Identifiers

PMID: 8460642
PMCID: PMC1682078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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