Article
Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21.
American journal of human genetics - 1 Apr 1993
Smith S A, Easton D F, Ford D, Peto J, Anderson K, Averill D, Stratton M, Ponder M, Pye C, Ponder B A
Abstract excerpt
In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at theta = .04) but only weak evidence in those without ovarian cancer. Recombinant ev...
Topics
- Alleles
- Breast Neoplasms
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- DNA, Neoplasm
- DNA, Satellite
- Family Health
- Female
- Genetic Linkage
- Genetic Markers
- Genetic Variation
- Humans
- Lod Score
- Male
- Middle Aged
- Neoplastic Syndromes, Hereditary