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Article

Molecular characterization of three loss-of-function mutations in the isopenicillin N-acyltransferase gene (penDE) of Penicillium chrysogenum.

Journal of bacteriology - 1 Aug 1994

Fernández F J, Gutierrez S, Velasco J, Montenegro E, Marcos A T, Martín J F

Abstract excerpt

Five mutants of Penicillium chrysogenum blocked in penicillin biosynthesis (npe) which are deficient in isopenicillin N-acyltransferase were isolated previously. Three of these mutants, npe6, npe7, and npe8, have been characterized at the molecular level and compared with npe10, a deletion mutant. Transcripts of normal size (1.15 kb) of the penDE genes, which encode isopenicillin N-acyltransferase, and also of...

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Identifiers

PMID: 7519594
DOI: 10.1128/jb.176.16.4941-4948.1994
PMCID: PMC196331

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