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Article

Direct involvement of the CreA transcription factor in penicillin biosynthesis and expression of the pcbAB gene in Penicillium chrysogenum.

Applied microbiology and biotechnology - 1 Aug 2014

Cepeda-García Cristina, Domínguez-Santos Rebeca, García-Rico Ramón O, García-Estrada Carlos, Cajiao Angela, Fierro Francisco, Martín Juan Francisco

Abstract excerpt

The transcription factor CreA is the main regulator responsible for carbon repression in filamentous fungi. CreA is a wide domain regulator that binds to regulatory elements in the promoters of target genes to repress their transcription. Penicillin biosynthesis and the expression of penicillin biosynthetic genes are subject to carbon repression. However, evidence of the participation of CreA in this regulation...

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PMID: 24818689
DOI: 10.1007/s00253-014-5760-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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