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Article

Biochemical characterization and molecular genetics of nine mutants of Penicillium chrysogenum impaired in penicillin biosynthesis.

The Journal of biological chemistry - 5 Jan 1993

Cantoral J M, Gutiérrez S, Fierro F, Gil-Espinosa S, van Liempt H, Martín J F

Abstract excerpt

Nine mutants of Penicillium chrysogenum (npe1 to npe8 and npe10) impaired in penicillin biosynthesis were screened after nitrosoguanidine mutation. Mutants npe1, npe4, npe5, npe6, npe7, npe8, and npe10 failed to synthesize significant levels of penicillin, whereas strains npe2 and npe3 synthesized about 20% of the penicillin level produced by the parental strain. Mutants npe5 and npe10 did not show...

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PMID: 8416976

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