Article
Mutants blocked in penicillin biosynthesis show a deletion of the entire penicillin gene cluster at a specific site within a conserved hexanucleotide sequence.
Applied microbiology and biotechnology - 1 Jan 1996
Fierro F, Montenegro E, Gutiérrez S, Martín J F
Abstract excerpt
The organization of the genes of the penicillin cluster has been studied in three different mutants of P. chrysogenum impaired in penicillin biosynthesis. The three blocked mutants (derived from the parental strain P. chrysogenum Bb-1) lacked the genes pcbAB, pcbC and penDE of the penicillin bios...
Topics
- Base Sequence
- Conserved Sequence
- Gene Deletion
- Genes, Bacterial
- Molecular Sequence Data
- Multigene Family
- Mutation
- Penicillins
- Penicillium chrysogenum
- Recombination, Genetic