Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genes for beta-lactam antibiotic biosynthesis.

Antonie van Leeuwenhoek - 1 Jan 1995

Martín J F, Gutiérrez S

Abstract excerpt

The genes pcbAB, pcbC and penDE encoding enzymes involved in the biosynthesis of penicillin have been cloned from Penicillium chrysogenum and Aspergillus nidulans. They are clustered in chromosome I (10.4 Mb) of P. chrysogenum, but they are located in chromosome II of Penicillium notatum (9.6 Mb)...

Topics

Amino Acid Sequence
Anti-Bacterial Agents
Bacteria
Cephalosporins
Cephamycins
Fungi
Genes, Bacterial
Genes, Fungal
Molecular Sequence Data
Mutation
Penicillins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7771766
DOI: 10.1007/BF00871213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7771766-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genes for beta-lactam antibiotic biosynthesis.PMID 7771766Read ↗

Molecular Regulation of β-Lactam Biosynthesis in Filamentous FungiSemantic proximity Read ↗

The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl-valine synthetase and linkage to the pcbC and penDE genes.Semantic proximity Read ↗

Mutants blocked in penicillin biosynthesis show a deletion of the entire penicillin gene cluster at a specific site within a conserved hexanucleotide sequence.Semantic proximity Read ↗

The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum.Semantic proximity Read ↗

Cloning and characterization of the isopenicillin N synthase gene of Streptomyces griseus NRRL 3851 and studies of expression and complementation of the cephamycin pathway in Streptomyces clavuligerus.Semantic proximity Read ↗

Direct involvement of the CreA transcription factor in penicillin biosynthesis and expression of the pcbAB gene in Penicillium chrysogenum.Semantic proximity Read ↗

Possible involvement of the lysine epsilon-aminotransferase gene (lat) in the expression of the genes encoding ACV synthetase (pcbAB) and isopenicillin N synthase (pcbC) in Streptomyces clavuligerus.Semantic proximity Read ↗

Microbial isopenicillin N synthase genes: structure, function, diversity and evolution.Semantic proximity Read ↗

Insight into the Genome of Diverse Penicillium chrysogenum Strains: Specific Genes, Cluster Duplications and DNA Fragment Translocations.Semantic proximity Read ↗

Cloning and characterization of the endogenous cephalosporinase gene, cepA, from Bacteroides fragilis reveals a new subgroup of Ambler class A beta-lactamases.Semantic proximity Read ↗

The biosynthetic gene cluster for the beta-lactam carbapenem thienamycin in Streptomyces cattleya.Semantic proximity Read ↗

Genome Sequence and Annotation of <i>Acremonium chrysogenum</i> , Producer of the β-Lactam Antibiotic Cephalosporin CSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.