Article
Characterization of a novel peroxisome membrane protein essential for conversion of isopenicillin N into cephalosporin C.
The Biochemical journal - 1 Dec 2010
Ullán Ricardo V, Teijeira Fernando, Guerra Susana M, Vaca Inmaculada, Martín Juan F
Abstract excerpt
The mechanisms of compartmentalization of intermediates and secretion of penicillins and cephalosporins in β-lactam antibiotic-producing fungi are of great interest. In Acremonium chrysogenum, there is a compartmentalization of the central steps of the CPC (cephalosporin C) biosynthetic pathway. In the present study, we found in the 'early' CPC cluster a new gene named cefP encoding a putative transmembrane...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.