Article
The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum.
Biochimie - 1 Feb 2009
Kosalková Katarina, García-Estrada Carlos, Ullán Ricardo V, Godio Ramiro P, Feltrer Raúl, Teijeira Fernando, Mauriz Elba, Martín Juan Francisco
Abstract excerpt
The biosynthesis of the beta-lactam antibiotic penicillin is an excellent model for the study of secondary metabolites produced by filamentous fungi due to the good background knowledge on the biochemistry and molecular genetics of the beta-lactam producing microorganisms. The three genes (pcbAB, pcbC, penDE) encoding enzymes of the penicillin pathway in Penicillium chrysogenum are clustered, but no penicillin...
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