Article
Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS.
Science (New York, N.Y.) - 22 Jul 1994
O'Dell T J, Huang P L, Dawson T M, Dinerman J L, Snyder S H, Kandel E R, Fishman M C
Abstract excerpt
Long-term potentiation (LTP) is a persistent increase in synaptic strength implicated in certain forms of learning and memory. In the CA1 region of the hippocampus, LTP is thought to involve the release of one or more retrograde messengers from the postsynaptic cell that act on the presynaptic terminal to enhance transmitter release. One candidate retrograde messenger is the membrane-permeant gas nitric oxide...
Topics
- Amino Acid Oxidoreductases
- Animals
- Arginine
- Electric Stimulation
- Endothelium
- Hippocampus
- In Vitro Techniques
- Long-Term Potentiation
- Mice
- Mutation
- Nitric Oxide