Behavioural and expressional phenotyping of nitric oxide synthase-I knockdown animals.

doi:10.1007/978-3-211-73574-9_10

Article

Behavioural and expressional phenotyping of nitric oxide synthase-I knockdown animals.

Journal of neural transmission. Supplementum - 1 Jan 2007

Wultsch T, Chourbaji S, Fritzen S, Kittel S, Grünblatt E, Gerlach M, Gutknecht L, Chizat F, Golfier G, Schmitt A, Gass P, Lesch K P, Reif A

Abstract excerpt

The gaseous messenger nitric oxide (NO) has been implicated in a wide range of behaviors, including aggression, anxiety, depression, and cognitive functioning. To further elucidate the physiological role of NO and its down-stream mechanisms, we conducted behavioral and expressional phenotyping of mice lacking the neuronal isoform of nitric oxide synthase (NOS-I), the major source of NO in the central nervous...

Topics

Animals
Arousal
Basic Helix-Loop-Helix Transcription Factors
CCAAT-Enhancer-Binding Protein-alpha
Cerebellum
Corpus Striatum
Emotions
Exploratory Behavior
Gene Expression Regulation
Hippocampus

Humans

KATP Channels

Maze Learning

Mental Recall

Mice

Mice, Inbred C57BL

Mice, Knockout

Nitric Oxide

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