Article

Type-I nNOS neurons orchestrate cortical neural activity and vasomotion

2025-01-21

Abstract excerpt

It is unknown how the brain orchestrates coordination of global neural and vascular dynamics. We sought to uncover the role of a sparse but unusual population of genetically distinct interneurons known as type-I nNOS neurons, using a novel pharmacological strategic to unilaterally ablate these neurons from the somatosensory cortex of mice. Region-specific ablation produced changes in both neural activity and vascu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2712b90b-f934-55c7-af1c-256ecfc85b04
DOI: 10.1101/2025.01.21.634042

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Type-I nNOS neurons orchestrate cortical neural activity and vasomotionDOI 10.1101/2025.01.21.634042Read

Characterization of iGABASnFR2 for in vivo mesoscale imaging of intracortical GABA dynamicsSemantic proximity Read

L-NA-sensitive rCBF augmentation during vibrissal stimulation in type III nitric oxide synthase mutant mice.Semantic proximity Read

Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype.Semantic proximity Read

Transcriptome-Inspired Spiking Simulations Uncover Human-Specific Prefrontal Dynamics and Provide a Mechanistic Platform for Species-Appropriate Disease ModelingSemantic proximity Read

A databank for intracellular electrophysiological mapping of the adult somatosensory cortexSemantic proximity Read

Cellular and Synaptic Diversity of Layer 2-3 Pyramidal Neurons in Human IndividualsSemantic proximity Read

Cortical Plasticity is associated with Blood-Brain-Barrier ModulationSemantic proximity Read

Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons.Semantic proximity Read

Hyperexcitable interneurons trigger cortical spreading depression in an Scn1a migraine model.Semantic proximity Read

Role of somatostatin-positive cortical interneurons in the generation of sleep slow wavesSemantic proximity Read

A novel key player in cognitive striatal processes: the Pthlh interneuronsSemantic proximity Read

Intercellular Conduction Optimizes Arterial Network Function and Conserves Blood Flow Homeostasis during Cerebrovascular ChallengesSemantic proximity Read