Neuronal nitric oxide synthase (NOS) regulates leukocyte-endothelial cell interactions in endothelial NOS deficient mice.

doi:10.1038/sj.bjp.0704234

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Article

Neuronal nitric oxide synthase (NOS) regulates leukocyte-endothelial cell interactions in endothelial NOS deficient mice.

British journal of pharmacology - 1 Sept 2001

Sanz M J, Hickey M J, Johnston B, McCafferty D M, Raharjo E, Huang P L, Kubes P

Abstract excerpt

1. The present study was designed to examine the possible role of neuronal nitric oxide synthase (nNOS) in regulation of leukocyte - endothelial cell interactions in the absence of endothelial nitric oxide synthase (eNOS), using intravital microscopy of the cremasteric microcirculation of eNOS(-/-) mice. 2. Baseline leukocyte rolling and adhesion revealed no differences between wild-type and eNOS(-/-) mice in...

Topics

Animals
Arginine
Cell Adhesion
Cell Communication
Endothelium, Vascular
Enzyme Inhibitors
Gene Expression Regulation, Enzymologic
Genotype
Hemodynamics
Hydrogen Peroxide
Indazoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intestinal Mucosa

Leukocytes

Male

Mice

Mice, Inbred C57BL

Mice, Inbred Strains

Mice, Knockout

Source

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Identifiers

PMID: 11564648
DOI: 10.1038/sj.bjp.0704234
PMCID: PMC1572945

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