Article
Enhanced astrocytic nitric oxide production and neuronal modifications in the neocortex of a NOS2 mutant mouse.
PloS one - 5 Sept 2007
Buskila Yossi, Abu-Ghanem Yasmin, Levi Yifat, Moran Arie, Grauer Ettie, Amitai Yael
Abstract excerpt
BACKGROUND: It has been well accepted that glial cells in the central nervous system (CNS) produce nitric oxide (NO) through the induction of a nitric oxide synthase isoform (NOS2) only in response to various insults. Recently we described rapid astroglial, NOS2-dependent, NO production in the neocortex of healthy mice on a time scale relevant to neuronal activity. To explore a possible role for astroglial NOS2...
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