Article
Enhanced long-term potentiation in vivo in dentate gyrus of NELL2-deficient mice.
Neuroreport - 1 Mar 2004
Matsuyama Shogo, Aihara Koutoku, Nishino Naoki, Takeda Satoshi, Tanizawa Katsuyuki, Kuroda Shun'ichi, Horie Masato
Abstract excerpt
NELL2 is a neuron-specific thrombospondin-1-like extracellular protein containing six epidermal growth factor-like domains and is highly expressed in the hippocampus. We have previously shown that NELL2 promotes survival of neurons through mitogen-activated protein kinases. To clarify the function of NELL2 in vivo, we have generated a novel strain of mice with a targeted mutation in the NELL2 gene and assessed...
Topics
- Animals
- Blotting, Northern
- DNA Fragmentation
- Dentate Gyrus
- Extracellular Space
- In Situ Hybridization
- Long-Term Potentiation
- Mice
- Mice, Knockout
- Mutation
- Nerve Tissue Proteins