Article
Nitric oxide mediates local activity-dependent excitatory synapse development.
Proceedings of the National Academy of Sciences of the United States of America - 29 Oct 2013
Nikonenko Irina, Nikonenko Alexander, Mendez Pablo, Michurina Tatyana V, Enikolopov Grigori, Muller Dominique
Abstract excerpt
Learning related paradigms play an important role in shaping the development and specificity of synaptic networks, notably by regulating mechanisms of spine growth and pruning. The molecular events underlying these synaptic rearrangements remain poorly understood. Here we identify NO signaling as a key mediator of activity-dependent excitatory synapse development. We find that chronic blockade of NO production in...
Topics
- Animals
- Cell Adhesion Molecules
- Cyclic GMP
- DNA Primers
- Evoked Potentials
- Genotype
- Hippocampus
- Learning
- Mice
- Microfilament Proteins
- Microscopy, Electron
- Nerve Net
- Neuronal Plasticity
- Nitric Oxide