Article
V(D)J recombinase-mediated HPRT mutations in peripheral blood lymphocytes of normal children.
Cancer research - 15 Mar 1996
Finette B A, Poseno T, Albertini R J
Abstract excerpt
Somatic mutations in the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene are rare occurrences in T-lymphocytes of normal individuals. Lacking pathogenic significance, these events can serve as reporters for assessing environmental genotoxicity. The present molecular analyses of hprt mutations arising spontaneously in normal children show that 30-35% of the genomic hprt changes in children under 5 years...
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