Article
Resistance to 2',3'-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase.
Antimicrobial agents and chemotherapy - 1 Feb 1994
Zhang D, Caliendo A M, Eron J J, DeVore K M, Kaplan J C, Hirsch M S, D'Aquila R T
Abstract excerpt
A human immunodeficiency virus type 1 variant resistant to zalcitabine (2',3'-dideoxycytidine [ddC]) was selected by sequential passage in the presence of increasing concentrations of ddC in peripheral blood mononuclear cell cultures. A mutation causing a lysine-to-arginine substitution was noted...
Topics
- Arginine
- Base Sequence
- Cell-Free System
- Codon
- DNA-Directed RNA Polymerases
- Deoxycytosine Nucleotides
- Drug Resistance, Microbial
- HIV Reverse Transcriptase
- Humans
- Lysine
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- RNA-Directed DNA Polymerase