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Article

Mutagenic study of codons 74 and 215 of the human immunodeficiency virus type 1 reverse transcriptase, which are significant in nucleoside analog resistance.

Journal of virology - 1 May 1994

Lacey S F, Larder B A

Abstract excerpt

Mutation in the human immunodeficiency virus type 1 reverse transcriptase (RT) at codon 215 has been shown to play a significant role in resistance to zidovudine (AZT). Substitution of threonine with tyrosine or phenylalanine alone confers decreased susceptibility to the inhibitor. In this study we constructed a panel of 10 viruses with different amino acids at this codon, including 7 novel mutants, and assessed...

Topics

Codon
Dose-Response Relationship, Drug
Drug Resistance, Microbial
HIV Reverse Transcriptase
HIV-1
Humans
Mutation
RNA-Directed DNA Polymerase
Zidovudine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7512165
DOI: 10.1128/JVI.68.5.3421-3424.1994
PMCID: PMC236837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7512165-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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