Article
Insertion of two amino acids combined with changes in reverse transcriptase containing tyrosine-215 of HIV-1 resistant to multiple nucleoside analogs.
AIDS (London, England) - 14 Jan 1999
de Jong J J, Goudsmit J, Lukashov V V, Hillebrand M E, Baan E, Huismans R, Danner S A, ten Veen J H, de Wolf F, Jurriaans S
Abstract excerpt
OBJECTIVE: To identify genotypic drug resistance patterns of HIV-1 in patients who were extensively pretreated with anti-HIV drugs and not responding to their current antiretroviral combination therapy. METHODS: Drug susceptibility of the viruses was tested by a phenotypic recombinant virus assay. Genotypic analysis of HIV resistance was performed by sequencing of the amino-terminal part of the corresponding...
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