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Article

Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation

1 Nov 1997

Abstract excerpt

The Leu-74 to Val (Leu74Val) mutation in human immunodeficiency virus type 1 reverse transcriptase (RT) develops as a consequence of didanosine (ddI) therapy and is associated with a decreased susceptibility to ddI. In this report, we provide evidence that the ddI-associated Leu74Val mutation confers a replication disadvantage to the virus. In a series of experiments, we have shown that (i) a cloned virus with an...

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PMID: 9343245
DOI: 10.1128/jvi.71.11.8846-8851.1997

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