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Article

A novel genetic pathway of human immunodeficiency virus type 1 resistance to stavudine mediated by the K65R mutation.

Journal of virology - 1 May 2003

García-Lerma J Gerardo, MacInnes Hamish, Bennett Diane, Reid Patrick, Nidtha Soumya, Weinstock Hillard, Kaplan Jonathan E, Heneine Walid

Abstract excerpt

Stavudine (d4T) and zidovudine (AZT) are thymidine analogs widely used in the treatment of human immunodeficiency virus type 1 (HIV-1)-infected persons. Resistance to d4T is not fully understood, although the selection of AZT resistance mutations in patients treated with d4T suggests that both drugs have similar pathways of resistance. Through the analysis of genotypic changes in nine recombinant viruses cultured...

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Source

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Identifiers

PMID: 12719561
DOI: 10.1128/jvi.77.10.5685-5693.2003
PMCID: PMC154026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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