Article
Human immunodeficiency virus type 1 pol gene mutations which cause decreased susceptibility to 2',3'-dideoxycytidine.
Antimicrobial agents and chemotherapy - 1 Jan 1992
Fitzgibbon J E, Howell R M, Haberzettl C A, Sperber S J, Gocke D J, Dubin D T
Abstract excerpt
To investigate whether human immunodeficiency virus type 1 pol gene mutations are selected during prolonged 2',3'-dideoxycytidine (ddC) therapy, we used the polymerase chain reaction to amplify a portion of the reverse transcriptase segment of the pol gene from the peripheral blood mononuclear ce...
Topics
- Acquired Immunodeficiency Syndrome
- Adult
- Amino Acid Sequence
- Base Sequence
- Drug Resistance, Microbial
- Genes, pol
- HIV-1
- Humans
- Hybridization, Genetic
- Male
- Molecular Sequence Data
- Mutation
- Zalcitabine