Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine.

doi:10.1128/AAC.38.2.275

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Article

Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine.

Antimicrobial agents and chemotherapy - 1 Feb 1994

Gu Z, Gao Q, Fang H, Salomon H, Parniak M A, Goldberg E, Cameron J, Wainberg M A

Abstract excerpt

The technique of in vitro selection was used to generate variants of the human immunodeficiency virus type 1 that are resistant to 2',3'-dideoxycytidine (ddC). Most of the pol regions of such viruses, including the complete reverse transcriptase open reading frame and portions of flanking protease and integrase genes, were cloned and sequenced, using PCR-based procedures. Mutations were variously detected at...

Topics

Amino Acid Sequence
Base Sequence
Cloning, Molecular
Codon
DNA Primers
Didanosine
Drug Resistance, Microbial
HIV Reverse Transcriptase
HIV-1
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lamivudine

Molecular Sequence Data

Mutagenesis, Site-Directed

Mutation

RNA-Directed DNA Polymerase

Zalcitabine

Zidovudine

Source

Open in PubMed Open full text

Identifiers

PMID: 7514855
DOI: 10.1128/AAC.38.2.275
PMCID: PMC284440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7514855-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine.PMID 7514855Read ↗

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