Article
The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine.
Antimicrobial agents and chemotherapy - 1 Jun 1993
Gao Q, Gu Z, Parniak M A, Cameron J, Cammack N, Boucher C, Wainberg M A
Abstract excerpt
Variants of human immunodeficiency virus type 1 that display 500- to 1,000-fold resistance to the (-) enantiomer of 2'-deoxy-3'-thiacytidine and approximately 4- to 8-fold resistance to 2',3'-dideoxycytidine and 2',3'-dideoxyinosine have been generated through in vitro selection with the former c...
Topics
- Antiviral Agents
- Base Sequence
- Cloning, Molecular
- Didanosine
- Drug Resistance, Microbial
- HIV-1
- Humans
- Lamivudine
- Methionine
- Mutagenesis, Site-Directed
- Mutation
- Stereoisomerism
- Valine
- Zalcitabine